Table 1.

Voltage dependence of activation and inactivation of BgNa_v1–1a and mutants.

Nav channel type	Activation		Inactivation		n
	V1/2 (mV)	k (mV)	V1/2 (mV)	k (mV)
BgNav1–1a	− 29.6 ± 1.3	4.6 ± 0.4	− 49.2±1.0	4.7 ± 0.1	11
IIIS1-E1K	− 31.3 ± 1.2	5.6 ± 0.2	−56.1 ± 0.9*	5.1 ± 0.1	26
IIIS1-E2K	− 30.8 ± 1.0	7.4 ± 0.4	− 61.9 ± 1.1*	5.2 ± 0.1	13
IIIS2-E2K	− 31.1 ± 1.6	6.6 ± 0.3	− 53.7 ± 1.2*	6.0 ± 0.2	13
IIIS2-D1K	−26.0 ± 0.9*	7.1 ± 0.2	− 43.7 ± 1.2*	3.7 ± 0.2	13
IIIR4E	− 36.2 ± 1.8*	4.6 ± 0.4	− 49.2 ± 1.0	4.7 ± 0.1	11
IIIS2-D1K/IIIR4E	− 41.2 ± 1.2*	8.1 ± 0.2	− 79.3 ± 1.5*	8.8 ± 0.5	15

The voltage dependence values of conductance and inactivation were fitted with a two-state Boltzmann equation to determine V_1/2, the voltage for half maximal conductance or inactivation, and k, the slope factor for conductance or inactivation. The values in the table represent the mean ± SEM, and n is the number of oocytes tested. The asterisks indicate significant differences as determined by one-way ANOVA (p < 0.05) with Scheffe’s post hoc analysis.