Table 3.
Comparison of baseline characteristics of cirrhosis patients who received platelet and those who did not
|
|
Before PSM analysis
|
After PSM analysis
|
||||
|
Characteristics
|
Platelets transfusion (n = 91)
|
No platelets transfusion (n = 822)
|
P
value
|
Platelet transfusion (n = 89)
|
No platelet transfusion (n = 89)
|
P
value
|
| Age (yr) | 42 (34-50) | 45 (35-54) | 0.012 | 42 (34-50) | 40 (30-50) | 0.716 |
| Sex (Male:Female) | 77 (84.6): 14 (15.4) | 685 (83.3): 137 (16.7) | 0.882 | 75 (84.3): 14 (15.7) | 80 (89.9): 9 (10.1) | 0.372 |
| Heart rate (per minute) | 90 (84-100) | 96 (86-110) | 0.016 | 90 (85-100) | 89 (82-100) | 0.546 |
| MAP (mm of Hg) | 81 (75-87) | 82 (74-90) | 0.341 | 81 (75-87) | 81 (73-88) | 0.968 |
| Hemoglobin (g/dL) | 7.7 (6.1-9.4) | 7.6 (6.1-9.4) | 0.890 | 7.7 (6.1-9.4) | 7.5 (6.3-9.0) | 0.720 |
| TLC (× 109/L) | 5.6 (3.1-8.3) | 6.6 (4.0-9.4) | 0.012 | 5.6 (3.1-8.3) | 7.0 (4.4-12.0) | 0.002 |
| Platelet count (× 109/L) | 40.0 (32.0-58.0) | 100.0 (63.0-139.0) | < 0.001 | 40.0 (32.0-58.0) | 81 (57-126) | < 0.001 |
| INR | 1.6 (1.3-2.0) | 1.5 (1.3-1.9) | 0.266 | 1.6 (1.3-2.0) | 1.7 (1.4-2.2) | 0.402 |
| Serum urea (mg/dL) | 41 (28-60) | 36 (24-64) | 0.864 | 41 (28-61) | 34 (24-69) | 0.369 |
| Creatinine (mg/dL) | 0.7 (0.5-1.0) | 0.8 (0.6-1.3) | 0.003 | 0.7 (0.5-1.0) | 0.8 (0.6-1.4) | 0.040 |
| Sodium (meq/L) | 140.2 (137.0-143.0) | 139.0 (135.0-142.0) | 0.023 | 140 (137-143) | 140 (135-143) | 0.529 |
| Bilirubin (mg/dL) | 1.7 (0.9-3.8) | 1.6 (0.9-3.0) | 0.771 | 1.7 (0.9-3.8) | 2.4 (1.3-4.8) | 0.071 |
| AST (IU/L) | 49 (34-79) | 51 (34-88) | 0.570 | 49 (34-79) | 67 (38-119) | 0.019 |
| ALT (IU/L) | 32 (22-58) | 35 (23-54) | 0.905 | 32 (22-58) | 41 (30-67) | 0.029 |
| Albumin (g/dL) | 3.2 (2.7-3.8) | 3.2 (2.7-3.8) | 0.897 | 3.2 (2.7-3.8) | 3.1 (2.6-3.6) | 0.355 |
| CTP | 7 (6-10) | 7 (6-9) | 0.119 | 8 (6-10) | 8 (6-10) | 0.186 |
| MELD | 14.6 (10.9-20.2) | 14.7 (11.1-20.3) | 0.878 | 14.6 (10.9-20.2) | 16.1 (12.5-24.1) | 0.079 |
| Ascites | 59 (64.8) | 397 (48.3) | 0.003 | 59 (66.3) | 58 (65.2) | 1.000 |
| HCC | 6 (6.6) | 29 (3.5) | 0.150 | 6 (6.7) | 4 (4.5) | 0.747 |
| HE | 15 (16.5) | 78 (9.5) | 0.044 | 15 (16.9) | 22 (24.7) | 0.268 |
| Endotherapy (yes) | 71 (78.0) | 640 (77.9) | 1.000 | 72 (80.9) | 71 (79.8) | 1.000 |
| Child class | 0.210 | 0.313 | ||||
| A | 33 (36.3) | 341 (41.5) | 31 (34.8) | 22 (24.7) | ||
| B | 34 (37.4) | 327 (39.8) | 34 (38.2) | 37 (41.6) | ||
| C | 24 (26.4) | 154 (18.7) | 24 (27.0) | 30 (33.7) | ||
| Etiology | 0.824 | 0.176 | ||||
| Alcohol | 38 (41.8) | 355 (43.2) | 37 (41.6) | 47 (52.8) | ||
| Other | 53 (58.2) | 467 (56.8) | 52 (58.4) | 42 (47.2) | ||
| RBC | 0.483 | 0.294 | ||||
| 0 | 49 (53.8) | 493 (60.0) | 48 (53.9) | 56 (62.9) | ||
| 1 | 15 (16.5) | 128 (15.6) | 14 (15.7) | 15 (16.9) | ||
| ≥ 2 | 27 (29.7) | 201 (24.5) | 27 (30.3) | 18 (20.2) | ||
| FFP transfusion | 22 (24.2) | 86 (10.5) | < 0.001 | 22 (24.7) | 22 (24.7) | 1.000 |
| Grade of varices low:high | 71 (78.0) | 714 (86.9) | 0.026 | 69 (77.5) | 84 (94.4) | 0.002 |
All values are represented as n (%) or median (IQR). AST: Aspartate transaminase; ALT: Alanine transaminase; CTP: Child-Turcotte-Pugh score; INR: Internationalized normalized ratio; EVL: Endoscopic variceal ligation; FFP: Fresh frozen plasma; HE: Hepatic encephalopathy; HCC: Hepatocellular carcinoma; MAP: Mean arterial pressure; MELD: Model for end stage liver disease; RBC: Red blood cells; TLC: Total leucocyte count.