Table 4.
Cox-proportional analysis of variables associated with 42-days rebleeding in the whole cohort and after propensity score matching
|
|
Whole cohort
|
After propensity score matching
|
||||||
|
Characteristics
|
Univariate analysis HR (95%CI)
|
P
value
|
Univariate analysis HR (95%CI)
|
P
value
|
Model 1 (Excluding CTP)
|
Model 2 (Including CTP)
|
||
|
|
|
|
|
|
Adjusted HR (95%CI)
|
P
value
|
Adjusted HR (95%CI)
|
P
value
|
| Age (yr) | 1.000 (0.987-1.013) | 0.973 | 1.007 (0.984-1.031) | 0.584 | ||||
| Sex | ||||||||
| Male | 1 | 1 | ||||||
| Female | 0.662 (0.393-1.114) | 0.120 | 1.330 (0.560-3.158) | 0.517 | ||||
| Heart rate (per minute) | 0.995 (0.986-1.004) | 0.298 | 1.011 (0.996-1.026) | 0.157 | ||||
| MAP (mm of Hg) | 0.979 (0.965-0.992) | 0.002 | 0.966 (0.938-0.996) | 0.024 | 9.972 (0.938-1.008) | 0.131 | 0.968 (0.936-1.001) | 0.057 |
| Hemoglobin (g/dL) | 0.969 (0.906-1.036) | 0.349 | 0.914 (0.800-1.045) | 0.189 | ||||
| TLC (× 109/L) | 1.023 (0.995-1.053) | 0.111 | 0.991 (0.933-1.052) | 0.761 | ||||
| Platelet count (× 109/L) | 0.999 (0.997-1.001) | 0.360 | 0.995 (0.989-1.001) | 0.129 | ||||
| INR | 1.528 (1.296-1.802) | < 0.001 | 1.427 (0.976-2.086) | 0.067 | 1.341 (0.784-2.295) | 0.284 | ||
| Serum urea (mg/dL) | 1.005 (1.001-1.008) | 0.012 | 1.004 (0.997-1.011) | 0.237 | ||||
| Creatinine (mg/dL) | 1.158 (1.021-1.314) | 0.023 | 1.031 (0.805-1.319) | 0.811 | ||||
| Sodium (meq/L) | 0.993 (0.966-1.022) | 0.647 | 0.980 (0.929-1.033) | 0.451 | ||||
| Bilirubin (mg/dL) | 1.065 (1.045-1.086) | < 0.001 | 1.016 (0.976-1.058) | 0.434 | ||||
| AST (IU/L) | 1.001 (1.000-1.001) | 0.005 | 1.001 (1.000-1.002) | 0.002 | 1.001 (1.000-1.002) | 0.284 | 1.001 (1.000-1.002) | 0.021 |
| ALT (IU/L) | 1.000 (0.998-1.002) | 0.920 | 1.000 (0.998-1.003) | 0.761 | ||||
| Albumin (g/dL) | 0.833 (0.672-1.031) | 0.093 | 0.543 (0.363-0.811) | 0.003 | 0.690 (0.431-1.105) | 0.122 | ||
| CTP | 1.255 (1.177-1.337) | < 0.001 | 1.169 (1.048-1.303) | 0.005 | - | 1.081 (0.959-1.220) | 0.203 | |
| MELD | 1.057 (1.038-1.077) | < 0.001 | 1.028 (0.995-1.063) | 0.102 | - | |||
| Ascites, yes | 2.525 (1.757-3.630) | < 0.001 | 1.906 (0.939-3.870) | 0.074 | 0.857 (0.376-1.953) | 0.713 | ||
| HCC, yes | 2.532 (1.367-4.690) | 0.003 | 0.370 (0.051-2.687) | 0.326 | ||||
| HE, yes | 3.969 (2.700-5.836) | < 0.001 | 2.489 (1.324-4.679) | 0.005 | 1.791 (0.836-3.836) | 0.134 | ||
| Endotherapy (yes) | 0.702 (0.480-1.027) | 0.069 | 0.999 (0.463-2.155) | 0.998 | ||||
| Child class | ||||||||
| A | 1 | 1 | ||||||
| B | 1.849 (1.187-2.879) | 0.007 | 1.811 (0.738-4.444) | 0.195 | ||||
| C | 4.653 (2.988-7.245) | < 0.001 | 3.695 (1.567-8.715) | 0.003 | ||||
| Etiology | ||||||||
| Alcohol | 1 | 0.095 | 1 | 0.124 | ||||
| Other | 0.753 (0.539-1.051) | 0.622 (0.339-1.140) | ||||||
| RBC (units) | ||||||||
| 0 | 1 | 1 | 1 | 1 | ||||
| 1 | 1.482 (0.944-2.327) | 0.087 | 1.162 (0.464-2.910) | 0.748 | 1.173 (0.460-2.992) | 0.738 | 1.253 (0.493-3.180) | 0.636 |
| ≥ 2 | 1.434 (0.979-2.098) | 0.064 | 2.571 (1.349-4.902) | 0.004 | 1.998 (0.962-4.152) | 0.064 | 1.900 (0.942-3.831) | 0.073 |
| FFP transfusion | 3.078 (2.096-4.518) | < 0.001 | 1.490 (0.777-2.858) | 0.220 | ||||
| Platelet transfusion | 2.613 (1.735-3.936) | < 0.001 | 2.204 (1.165-4.172) | 0.015 | 2.924 (1.448-5.903) | 0.003 | 2.702 (1.345-5.429) | 0.005 |
| Grade of varices (high) | 0.829 (0.526-1.308) | 0.421 | 0.671 (0.311-1.446) | 0.308 | ||||
AST: Aspartate transaminase; ALT: Alanine transaminase; CTP: Child-Turcotte-Pugh score; INR: Internationalized normalized ratio; EVL: Endoscopic variceal ligation; FFP: Fresh frozen plasma; HE: Hepatic encephalopathy; HCC: Hepatocellular carcinoma; MAP: Mean arterial pressure; MELD: Model for end stage liver disease; RBC: Red blood cells; TLC: Total leucocyte count.