Table 5.
Cox-proportional analysis of variables associated with 42-days mortality in the whole cohort and after propensity score matching
|
Whole cohort
|
After propensity score matching
|
|||||
|
Characteristics
|
Univariate analysis HR (95%CI)
|
P
value
|
Univariate analysis HR (95%CI)
|
P
value
|
Adjusted HR (95%CI)
|
P
value
|
| Age (yr) | 1.010 (0.998-1.022) | 0.118 | 1.016 (0.993-1.039) | 0.174 | ||
| Sex | ||||||
| Male | 1 | 1 | ||||
| Female | 0.682 (0.427-1.088) | 0.108 | 0.889 (0.350-2.256) | 0.804 | ||
| Heart rate (per minute) | 0.999 (0.990-1.007) | 0.759 | 1.004 (0.989-1.021) | 0.581 | ||
| MAP (mm of Hg) | 0.988 (0.976-1.000) | 0.046 | 0.996 (0.967-1.027) | 0.816 | ||
| Hemoglobin (g/dL) | 0.949 (0.892-1.010) | 0.100 | 0.992 (0.872-1.128) | 0.903 | ||
| TLC (× 109/L) | 1.047 (1.023-1.071) | < 0.001 | 1.034 (0.986-1.084) | 0.172 | ||
| Platelet count (× 109/L) | 0.998 (0.995-1.000) | 0.053 | 0.998 (0.992-1.003) | 0.422 | ||
| INR | 1.903 (1.689-2.143) | < 0.001 | 1.656 (1.246-2.201) | 0.001 | 1.361 (0.825-2.244) | 0.228 |
| Serum urea (mg/dL) | 1.009 (1.006-1.012) | < 0.001 | 1.005 (0.998-1.012) | 0.142 | ||
| Creatinine (mg/dL) | 1.374 (1.263-1.495) | < 0.001 | 1.205 (1.004-1.446) | 0.046 | 0.985 (0.771-1.258) | 0.901 |
| Sodium (meq/L) | 0.991 (0.966-1.017) | 0.494 | 0.996 (0.943-1.052) | 0.876 | ||
| Bilirubin (mg/dL) | 1.077 (1.061-1.094) | < 0.001 | 1.040 (1.010-1.072) | 0.010 | 1.013 (0.967-1.061) | 0.588 |
| AST (IU/L) | 1.001 (1.001-1.002) | < 0.001 | 1.001 (1.001-1.002) | < 0.001 | 1.001 (1.000-1.002) | 0.113 |
| ALT (IU/L) | 1.002 (1.001-1.002) | < 0.001 | 1.001 (0.999-1.003) | 0.249 | ||
| Albumin (g/dL) | 0.671 (0.548-0.821) | < 0.001 | 0.641 (0.433-0.948) | 0.026 | 0.964 (0.619-1.501) | 0.871 |
| CTP | 1.369 (1.294-1.448) | < 0.001 | 1.239 (1.114-1.378) | < 0.001 | ||
| MELD | 1.097 (1.080-1.115) | < 0.001 | 1.060 (1.029-1.091) | < 0.001 | ||
| Ascites, yes | 2.673 (1.911-3.739) | < 0.001 | 1.876 (0.926-3.799) | 0.080 | 1.043 (0.431-2.525) | 0.925 |
| HCC, yes | 1.637 (0.836-3.206) | 0.150 | 1.258 (0.390-4.063) | 0.701 | ||
| HE, yes | 5.686 (4.102-7.881) | < 0.001 | 3.825 (2.014-6.953) | < 0.001 | 2.586 (1.260-5.307) | 0.010 |
| Endotherapy, yes | 0.548 (0.394-0.760) | < 0.001 | 0.423 (0.226-0.790) | 0.007 | 0.589 (0.296-1.169) | 0.130 |
| Child class | ||||||
| A | 1 | 1 | ||||
| B | 1.771 (1.142-2.747) | 0.011 | 1.002 (0.395-2.538) | 0.997 | ||
| C | 6.785 (4.502-10.227) | < 0.001 | 3.759 (1.698-8.321) | 0.001 | ||
| Etiology | ||||||
| Alcohol | 1 | 1 | 1 | |||
| Other | 0.641 (0.473-0.870) | 0.004 | 0.600 (0.329-1.094) | 0.096 | 0.920 (0.470-1.799) | 0.808 |
| RBC | ||||||
| 0 | 1 | 1 | ||||
| 1 | 1 0.966 (0.629-1.484) | 0.874 | 1.158 (0.522-2.567) | 0.718 | ||
| ≥ 2 | 0.741 (0.505-1.086 | 0.125 | 1.024 (0.504-2.081) | 0.948 | ||
| FFP transfusion | 2.532 (1.762-3.637) | < 0.001 | 1.923 (1.040-3.555) | 0.037 | 1.066 (0.510-2.230) | 0.865 |
| Platelet transfusion | 1.489 (0.958-2.312) | 0.077 | 1.098 (0.608-1.984) | 0.757 | ||
| Grade of varices (high) | 1.348 (0.826-2.198) | 0.232 | 0.880 (0.392-1.975) | 0.757 | ||
AST: Aspartate transaminase; ALT: Alanine transaminase; CTP: Child-Turcotte-Pugh score; INR: Internationalized normalized ratio; EVL: Endoscopic variceal ligation; FFP: Fresh frozen plasma; HE: Hepatic encephalopathy; HCC: Hepatocellular carcinoma; MAP: Mean arterial pressure; MELD: Model for end stage liver disease; RBC: Red blood cells; TLC: Total leucocyte count.