Table 2.
Summary of the list genes that are the most upregulated and downregulated in our meta-analysis of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis liver samples compared to healthy controls
|
Top upregulated genes
|
Top downregulated genes
|
||||||
| NAFLD vs Healthy | NASH vs Healthy | NAFLD vs Healthy | NASH vs Healthy | ||||
| XIST | 0.326 | Crystallin alpha A | 1.185 | LINC02535 | -0.198 | MT1L | -0.454 |
| PEG10 | 0.267 | CYP7A1 | 0.409 | GPR88 | -0.194 | CYR61 | -0.386 |
| SUCO | 0.252 | BBOX1 | 0.381 | CYP1A1 | -0.170 | FOSB | -0.339 |
| CBWD5 | 0.239 | TAF4B | 0.355 | IGFBP2 | -0.168 | IGFBP2 | -0.326 |
| TMEM154 | 0.228 | FNDC5 | 0.346 | P4HA1 | -0.166 | FOS | -0.275 |
| HMGCR | 0.225 | MROH2A | 0.293 | TSPAN13 | -0.159 | CAPZA3 | -0.254 |
| LINC00885 | 0.216 | Fc alpha and mu receptor | 0.265 | NR4A2 | -0.148 | CSRNP1 | -0.254 |
| Chitinase 3 Like 1 | 0.186 | IL13RA2 | 0.252 | PER3 | -0.145 | PCDHB19P | -0.252 |
| MEP1B | 0.181 | ABHD1 | 0.250 | SHBG | -0.135 | Nicotinamide phosphoribosyltransferase | -0.240 |
| Phosphodiesterase 11A | 0.180 | Muscular LMNA interacting protein | 0.229 | CENPO | -0.131 | RASD1 | -0.237 |
NAFLD: Non-alcoholic fatty liver disease; NASH: Non-alcoholic steatohepatitis, PEG10: Paternally expressed imprinted gene 10; SHBG: Sex hormone-binding globulin.