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. Author manuscript; available in PMC: 2023 May 1.
Published in final edited form as: Adv Biol Regul. 2022 Jan 26;84:100861. doi: 10.1016/j.jbior.2022.100861

Figure 2. Role of C/EBPγ in the integrated stress response.

Figure 2.

Cellular stress promotes eukaryotic initiation factor 2α (EIF2) phosphorylation which increases CEBPG transcription and translation of ATF4. Under conditions of amino acid deprivation or oxidative stress, ATF4 heterodimerizes with C/EBPγ to mediate transcription of genes necessary to mount the cellular response (i.e., tRNA charging, folate metabolism, amino acid synthesis).