. 2022 Aug 1;65(15):10567–10587. doi: 10.1021/acs.jmedchem.2c00722

Table 2. Solubility in Water (D₂O), Octanol/Water Partition Coefficient (log P_ow), and Residual Ruthenium Complex in D₂O (after 48 h) and DMSO-d₆/DMEM-d (1:4 v/v, Except 1:3 v/v in the Case of 4; after 24 h) Solutions Maintained at 37 °C.

compound	solubility/10^–3 mol·L^–1 (D₂O, 21°C)^a	log P_ow	residual complex % in D₂O^a^,^b	residual complex % in DMEM-d/ DMSO-d₆^a^,^b
1		1.18 ± 0.05	69^c	88
2	4.5	–0.33 ± 0.07	89	51
3	3.4	–0.15 ± 0.03	100	100
4	2.4	0.58 ± 0.06	100	93
5	3.4	–0.05 ± 0.05	100	98
6	1.9	1.11 ± 0.07	100	100
7	3.1	–0.02 ± 0.05	100	95
8	1.1	0.34 ± 0.01	92	98
9	4.6	–0.20 ± 0.05	93	97

Calculated by ¹H NMR (Me₂SO₂ as the internal standard).

Sum of chloro (2–9) and aquo (2^W–9^W) complexes.

DMSO-d₆/D₂O (4:1 v/v) mixture.

Table 2. Solubility in Water (D2O), Octanol/Water Partition Coefficient (log Pow), and Residual Ruthenium Complex in D2O (after 48 h) and DMSO-d6/DMEM-d (1:4 v/v, Except 1:3 v/v in the Case of 4; after 24 h) Solutions Maintained at 37 °C.