Skip to main content
. 2022 Aug 1;65(15):10567–10587. doi: 10.1021/acs.jmedchem.2c00722

Table 3. IC50 Values (μM) Determined by the MTT Test after 72 h of Treatmenta.

  MCF-7 HeLa 518A2 HCT116 RD MRC5pd30 SIb
1 2.4 ± 0.6 4.0 ± 0.4 2.6 ± 0.4 1.5 ± 0.1 2.2 ± 0.2 5.8 ± 0.7 2.3
2 32 ± 4 53 ± 4 26 ± 4 25 ± 2 26 ± 5 76 ± 1 2.4
3 38 ± 8 91 ± 3 33 ± 5 25 ± 1 27 ± 4 83.6 ± 0.5 2.0
4 37 ± 7 36 ± 1 35 ± 4 25 ± 2 25 ± 3 56.6 ± 0.7 1.8
5 32 ± 5 54 ± 6 31 ± 3 30 ± 2 23 ± 2 63 ± 4 1.9
6 46 ± 7 54 ± 14 38 ± 8 31 ± 2 38 ± 6 82 ± 4 2.0
7 6 ± 1 10 ± 2 6.8 ± 0.8 6.7 ± 0.4 6 ± 1 24 ± 1 3.4
8 10 ± 2 15 ± 1 10 ± 2 8 ± 2 6.6 ± 0.7 19.7 ± 0.4 2.0
9 43 ± 7 36 ± 2 38 ± 7 35 ± 6 24 ± 3 50.8 ± 0.4 1.5
cisplatin 13 ± 3c 14 ± 3c 2.6 ± 0.7d 8 ± 1c 4.6 ± 0.3 11.7 ± 0.8c 1.1
a

The results are expressed as mean values ± SD from at least three independent experiments.

b

Selectivity index (SI) was calculated as IC50 for noncancerous MRC-5pd30 vs the average IC50 value of cancer cell lines.

c

Data taken from ref (63).

d

Data taken from ref (64).