Table 2. Chemical Stability, Solubility, Permeability, and Metabolic Stability of 2-(Quinolin-4-yloxy)acetamide 6m.

	chemical Stabilitya			solubilityb		permeability	metabolic stability
entry	pH 1.2c (%)	pH 7.4d (%)	pH 9.1e (%)	pH 1.2c (mM)	pH 7.4d (μM)	PAMPA (10–6 cm/s)	Clintf (mL/min/kg)	t1/2g (min)
6m	58.3	100	62.1	>2.5	31.4	4.5	7.5	176

^aPercentage of remaining compound after incubation at 37 °C for 24 h.

^bSolubility was determined after incubation at 25 °C for 4 h.

^cUsing a 0.1 M HCl solution.

^dUsing PBS.

^eUsing a 0.1 M NH₄HCO₃ solution.

^fIntrinsic clearance of rat liver microsomes.

^gHalf-life.