. 2022 Jul 21;13(8):1337–1344. doi: 10.1021/acsmedchemlett.2c00254

kg) Administration^a.

group	parameters	NPA	RSE (%)
intravenous	CL (L/h/kg)	0.088	11.7
	V₁ (L/kg)	0.215	22.6
	Q (L/h/kg)	0.339	33
	V₂ (L/kg)	0.0892	24.1
oral	CL/F (L/h/kg)	0.226	18.0
	V₁/F (L/kg)	0.460	29.0
	K_a (h^–1)	3.01	58.0
	F (%)	51.0

NPA = naïve pooled approach. CL = clearance. V₁ = volume of central the compartment. Q = intercompartmental clearance. V₂ = volume of the peripheral compartment. K_a = absorption rate constant. F = bioavailability.

Table 3. Pharmacokinetic Parameters of 2-(Quinolin-4-yloxy)acetamide 6m after Intravenous (25 mg/kg, 61.6 μmol/kg) and Oral (121.6 mg/kg, 300 μmol/kg) Administrationa.

Table 3. Pharmacokinetic Parameters of 2-(Quinolin-4-yloxy)acetamide 6m after Intravenous (25 mg/kg, 61.6 μmol/kg) and Oral (121.6 mg/kg, 300 μmol/kg) Administration^a.