Table 1. Comparison of Various In Vitro, Physicochemical, and In Vivo Properties for MMV048 and UCT943.

	property	MMV048	UCT943
In vitro potency	PvPI4K IC50	3.4 nM	23 nM
	PfNF54 IC50	28 nM	5.4 nM
	PfK1 IC50	25 nM	4.7 nM
physicochemical property	log D7.4	2.60 (0.01)	–0.27 (0.03)
	thermodynamic solubility (pH)a	4.2 μg·mL−1 (6.5)	110 μg·mL−1(6.0)
	Mol wt	393.4 g·mol–1	427.4 g·mol–1
	pKa (measured)	4.0 (0.07)	7.45 (0.05)
cardiotoxicity risk	hERG IC50	>11 μM	10 μM
life cycle stage activity	Pc liver hypnozoites/schizonts IC50	64 nM	<10 nM
	Pb liver schizonts IC50	46 nM	0.92 nM
	Pv liver hypnozoites/schizonts IC50	<100 nM	<100 nM
	Pf/Pv ex vivo	202 nM	29 nM
	Pf early gametocytes IC50	215 nM	134 nM
	Pf late/mature gametocytes IC50	140 nM	66 nM
	Pf gamete (male/female) IC50	91/139 nM	83/87 nM
	Pf oocyst reduction IC50	111 nM (indirect)	96 nM
efficacy	Pb ED90 (NOD-scid IL-2Rγnull mouse)	1.1 mg·kg–1	1.0 mg·kg–1
	Pf ED90 (NOD-scid IL-2Rγnull mouse)	0.57 mg·kg–1	0.25 mg·kg–1