. 2022 Jul 14;13(8):1278–1285. doi: 10.1021/acsmedchemlett.2c00166

Table 2. Pharmacokinetic Data for Doxophylline and Its Deuterated Analogues d₄-Doxophylline and d₇-Doxophylline Following Single-Dose Administration in minipigs.

parameter	doxophylline	d₄-doxophylline	d₇-doxophylline
Intravenous (5 mg/kg)
t_1/2 (h)	6.2	6.2	6.5
C_max (μg/L)	7501	7421	8265
AUC_0–t (μg L^–1 h^–1)	47729	49190	47009
CL (L h^–1 kg^–1)	0.1	0.1	0.1
Oral (20 mg/kg)
t_1/2 (h)	11.0	10.8	12.6
C_max (μg/L)	13961	15811	12998
AUC_0–t (μg L^–1 h^–1)	217271	235790	222429
CL/F (L h^–1 kg^–1)	0.07	0.07	0.07

Table 2. Pharmacokinetic Data for Doxophylline and Its Deuterated Analogues d4-Doxophylline and d7-Doxophylline Following Single-Dose Administration in minipigs.