Skip to main content
. 2022 Aug 1;13(8):1351–1357. doi: 10.1021/acsmedchemlett.2c00280

Table 3. Introducing a Methyl Substituent to the Indole Ring.

graphic file with name ml2c00280_0011.jpg

compd R1 R2 R3 R4 R5 rh-renin IC50 (FRET, nM)a hPRA IC50 (nM)b MW ClogP BEI
15 H H H H H 13 84 371.5 2.30 21.2
16 Me H H H H >10000   385.5 2.75  
17 H Me H H H 5.8 54 385.5 2.80 21.3
18 H H Me H H 274   385.5 2.80 17.0
19 H H H Me H 19 74 385.5 2.80 20.0
20 H H H H Me 9.3 103 385.5 2.80 20.8
a

IC50 values are shown as the mean of duplicate measurements and calculated from the concentration–inhibition curve using Origin software (version 5.0, Microcal Software, Inc.).

b

IC50 values are shown as the mean of duplicate measurements and calculated from the concentration–inhibition curve using SAS software (version 9.1.3, SAS Institute Inc.).