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Heat map of the effect of HOX gene expression on survival in TCGA patients. In adult tissues HOX genes display tissue-restricted expression, and hyper- or re-activation of HOX gene expression in tumors is generally associated with poor survival in most cases. Red, HOX genes actively repaired from oxidative DNA damage by acetylated base excision repair DNA glycosylase NEIL1. Reproduced from (23) by permission of Oxford University Press.
