Fig. 7.

Hyperphosphorylated tau contributes to v by inducing necroptosis and inflammation mediated by activating the RIPK1/RIPK3/MLKL and NF-κB pathways. Hyperphosphorylated tau promotes necroptosis by activating RIPK1/RIPK3/MLKL axis. Meanwhile, necroptosis is accompanied by the up regulation of pro-inflammatory factors transcription mediated by NF-κB pathway. Furthermore, microglia is activated by pro-inflammatory factors and jointly lead to neuronal cells death. Necroptosis and pro-inflammatory factors induction could be blocked by inhibition of RIPK1. However, NF-κB inhibitors can down regulate the transcription of pro-inflammatory factors, but promote necroptosis