Table 2.

Influence of diet, AGPs, and combined treatment (“interaction” column) on microbiome structure as measured by PERMANOVA using weighted UniFrac distances

GI site	Time	Diet (Accounting for AGPs)		AGPs (Accounting for diet)		Interaction
		R2	p-val	R2	p-val	R2	p-val	PERMDISP
Gizzard	D10	0.779	***	0.008	0.444	0.015	0.282	0.622
	D24	0.325	***	0.032	0.525	0.127	*	0.136
	D40	0.741	***	0.014	0.332	0.012	0.383	0.475
Duodenum	D10	0.121	*	0.227	**	0.052	0.229	0.16
	D24	0.105	0.169	0.024	0.856	0.023	0.863	0.988
	D40	0.064	0.218	0.125	*	0.037	0.637	**
Jejunum	D10	0.404	***	0.085	0.085	0.034	0.356	0.536
	D24	0.014	0.897	0.05	0.582	0.079	0.336	0.7332
	D40	0.053	0.386	0.049	0.442	0.035	0.67	0.363
Ileum	D10	0.297	***	0.202	**	0.098	*	0.547
	D24	0.187	**	0.024	0.808	0.074	0.218	0.81
	D40	0.308	***	0.025	0.609	0.029	0.529	0.182
Ceca	D10	0.13	0.052	0.04	0.486	0.085	0.141	0.941
	D24	0.249	**	0.066	0.229	0.043	0.461	**
	D40	0.105	**	0.136	***	0.077	*	0.066
Colon	D10	0.118	0.054	0.099	0.101	0.039	0.549	0.97
	D24	0.106	0.206	0.034	0.752	0.12	0.164	0.89
	D40	0.113	0.053	0.1	0.075	0.035	0.583	0.737

PERMDISP displays p-values as calculated through the PERMDISP test. Statistical significance is represented by the following: *p < 0.05; **p < 0.01; ***p < 0.001