Table 4.
Summary of grade 3/4 toxicity in patients treated by triplet chemotherapy plus anti-EGFR agents
| Author | Total | Neutropenia | FN | Thrombopnia | Diarrhea | Nausea/vomiting | Anorexia | Stomatitis | Asthenia | Skin toxicity | Neurotoxicity | HFS | Hypomagnesemia | Others |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| C Garufi | 43 | 2 | - | - | 15 | 4 | - | - | 5 | 6 | - | - | - | 3 |
| Sougklakos, Ia | 30 | 7 | NA | NA | 16 | NA | NA | NA | NA | 13 | 5 | NA | NA | NA |
| ERIC ASSENAT | 42 | 16 | 2 | 5 | 22 | 4 | 10 | - | 13 | 14 | 8 | 4 | - | 4 |
| Z Saridaki | 30 | 7 | 1 | 2 | 16 | 5 | - | 3 | - | 1 | - | 1 | - | 1 |
| Folprecht, Ga | 28 | 13 | NA | NA | NA | NA | NA | NA | NA | 5 | NA | NA | NA | NA |
| Fornaro, L | 37 | 18 | 2 | - | 13 | 5 | - | 5 | 10 | 5 | 3 | 1 | 5 | - |
| Bendell, J. C | 15 | 2 | - | 1 | 5 | 1 | 2 | - | 3 | 3 | - | 1 | 1 | 2 |
| Cremolini, C | 116 | 36 | 4 | - | 21 | 3 | 4 | 7 | 11 | 18 | - | - | - | - |
| D Modest | 63 | 10 | - | - | 16 | 6 | - | 6 | 5 | 9 | 2 | 4 | 3 | 17 |
| Ogata, T | 17 | 10 | - | - | 2 | 1 | - | - | - | - | - | - | 2 | - |
| E. Samalina | 70 | 15 | 2 | NA | 22 | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Deng, Y | 67 | 21 | 2 | 1 | 5 | 1 | - | 1 | 1 | - | 3 | - | - | 6 |
| Akihito Tsujia | 173 | NA | NA | NA | 21 | NA | NA | NA | NA | 21 | NA | NA | 7 | NA |
| Total | 731 | 157 | 13 | 9 | 174 | 30 | 16 | 22 | 48 | 95 | 21 | 11 | 18 | 33 |
aToxicity profile uncompleted; FN febrile neutropenia, HFS hand/foot syndrome, NA not available