Table 2.

Net reclassification improvement of adding 24 metabolites into a conventional risk prediction model

	Conventional prediction model	Updated model
Incident dementia in 10 years	Risk (%)	<5	>5
Yes	<5	668	48
	>5	6	76
No	<5	101,185	654
	>5	353	823

Values are n. Patients in the upper-right cell were rightfully up-reclassified (n=48, and 6 patients were mistakenly down-reclassified), indicating an improved sensitivity. Patients in the lower-left cell were rightfully down-reclassified (n=353, and 654 patients mistakenly up-reclassified), indicating an undermined specificity. NRI (SE) = 0.0497 (0.00921), P value <0.001·