Table 1.
Baseline Demographics and Clinical Characteristics
| Total cohort N=38,528 | Infertility N=5399 | No Infertility N=33,129 | p-value | |
|---|---|---|---|---|
|
| ||||
| Age, years | 63 ± 7 | 63 ± 7 | 63 ± 7 | 0.68 |
| Race/Ethnicity | ||||
| Non-Hispanic White, n (%) | 19,213 (50%) | 2884 (53%) | 16329 (49%) | <0.001 |
| Black, n (%) | 12,826 (33%) | 1663 (31%) | 11163 (34%) | <0.001 |
| Hispanic, n (%) | 5588 (15%) | 718 (13%) | 4870 (15%) | 0.01 |
| Traditional CV risk factors | ||||
| Systolic blood pressure, | ||||
| mmHg | 129 ± 18 | 129 ± 18 | 129 ± 18 | 0.95 |
| Hypertension treatment, n (%) | 11,499 (30%) | 1577 (29%) | 9922 (30%) | 0.27 |
| BMI, kg/m2 | 29.6 ± 6.3 | 29.4 ± 6.2 | 29.6 ± 6.3 | 0.04 |
| DM, n (%) | 2790 (7%) | 382 (7%) | 2408 (7%) | 0.61 |
| Total cholesterol, mg/dL | 220 ± 45 | 218 ± 45 | 221 ± 45 | 0.01 |
| HDL cholesterol, mg/dL | 56 ± 15 | 56 ± 15 | 56 ± 14 | 0.01 |
| Hyperlipidemia, n (%) | 5542 (14%) | 786 (15%) | 4756 (14%) | 0.69 |
| Former smoker, n (%) | 14,808 (38%) | 2259 (42%) | 12,549 (38%) | <0.001 |
| Current smoker, n (%) | 3906 (10%) | 590 (11%) | 3316 (10%) | 0.04 |
| Coronary heart disease, n (%) | 1097 (3%) | 166 (3%) | 931 (3%) | 0.28 |
| 10-year ASCVD Risk, % | 7 (10) | 7 (10) | 7 (10) | 0.26 |
| Infertility-related risk factors | ||||
| Irregular menses, n (%) | 6424 (17%) | 1368 (24%) | 5056 (15%) | <0.001 |
| Premature menopause, n (%) | 11669 (30%) | 1872 (35%) | 9797 (30%) | <0.001 |
| Waist circumference, cm | 90 ±14 | 89 ±14 | 90 ± 14 | 0.38 |
| Thyroid disease, n (%) | 7342 (19%) | 1278 (24%) | 6064 (18%) | <0.001 |
Values are means (standard deviations) or medians (inter-quartile ranges) unless otherwise noted.
Abbreviations: ASCVD = atherosclerotic cardiovascular disease, DM = diabetes, HDL = high-density lipoprotein, HF = heart failure, HFpEF = heart failure with preserved ejection fraction, HFrEF = heart failure with reduced ejection fraction, LVEF = left ventricular ejection fraction.