. Author manuscript; available in PMC: 2023 Apr 26.

Published in final edited form as: J Am Coll Cardiol. 2022 Apr 26;79(16):1594–1603. doi: 10.1016/j.jacc.2022.02.020

Table 2.

Association of infertility with incident heart failure and heart failure subtypes

	Incident HF events	Age-adjusted		Multivariable-adjusted
	Incident HF events	HR (95% CI)	p-value	HR (95% CI) p-value

Overall HF	2373	1.16 (1.04–1.29)	0.008	1.16 (1.04–1.30)	0.006
HFpEF	1133	1.26 (1.08–1.47)	0.003	1.27 (1.09–1.48)	0.002
HFrEF	807	0.98 (0.80–1.19)	0.88	0.97 (0.80–1.18)	0.78

MV model adjusted for age, BMI, systolic blood pressure, hypertension treatment, DM, hyperlipidemia, smoking status, baseline CHD, and cohort. Covariates ascertained at study baseline. Abbreviations: CI = confidence interval, HF = heart failure, HFpEF = heart failure with preserved ejection fraction, HFrEF = heart failure with reduced ejection fraction, HR = hazard ratio.