Table 3.

Cross-sectional associations of traditional cardiovascular and infertility-related risk factors with infertility

	Age-adjusted analysis		Stepwise Regression*
	OR (95% CI)	p-value	OR (95% CI)	p-value
Traditional CV risk factors
Age	0.99 (0.96–1.02)	0.47	0.98 (0.95–1.01)	0.21
BMI	0.97 (0.94–1.00)	0.04	0.96 (0.93–0.99)	0.01
Non-Hispanic White race/ethnicity	1.16 (1.09–1.25)	<0.001	1.10 (1.03–1.19)	0.009
Black race	0.91 (0.85–0.98)	0.008	-	-
Hispanic ethnicity	0.93 (0.85–1.01)	0.10	-	-
Systolic blood pressure	1.01 (0.98–1.04)	0.62	-	-
Hypertension treatment	0.98 (0.92–1.05)	0.56	-	-
DM treatment	0.99 (0.88–1.11)	0.85	-	-
Former smoker	1.18 (1.11–1.25)	<0.001	1.19 (1.12–1.27)	<0.001
Current smoker	1.10 (1.00–1.21)	0.049	1.14 (1.03–1.26)	0.01
Hyperlipidemia	1.03 (0.95–1.12)	0.50	-	-
Infertility-related risk factors
Irregular menses	1.88 (1.75–2.01)	<0.001	1.84 (1.72–1.97)	<0.001
Early menopause	1.28 (1.20–1.36)	<0.001	1.26 (1.18–1.34)	<0.001
Waist circumference	0.99 (0.96–1.01)	0.31	-	-
Thyroid disease	1.38 (1.29–1.48)	<0.001	1.33 (1.24–1.42)	<0.001

OR: odds ratio per dichotomous variable or 1 standard deviation increase in continuous variable.

^*Stepwise model: age and cohort forced, entry at P<0.10, retention at P<0.05.

Abbreviations: BMI = body mass index, CI = confidence interval, CV = cardiovascular, DM = diabetes mellitus.