TABLE 1.
Characteristics of 126 patients with an open atrial septal defect and 23 controls based on a nationwide cohort study in Denmark.
| Open ASD n = 27 | Spontaneously closed ASD n = 99 | Controls n = 23 | |
| Females, n (%) | 17 (63) | 59 (60) | 14 (61) |
| Age, years | 33 (26–41) | 24 (22–35)*† | 30 (26–41) |
| BMI, kg/m2 | 23.7 (20.4–29.0) | 24.2 (21.9–28.1) | 23.1 (22.0–24.2) |
| Weight, kg | 72 (57–88) | 72.5 (59–85) | 67 (62–78) |
| Height, cm | 170 (167–179) | 170 (162–180) | 172 (168–177) |
| Smoking, n (%) | 8 (29.63) | 25 (25.25) | 3 (13.04) |
| Atrial fibrillation, n (%) | 0 (0) | 2 (2) | – |
| LV ejection fraction, % | 62 (60–65) | 60 (60–65) | – |
| RV FAC % | 52 (50–55) | 52 (50–56) | – |
| TR, mmHg | 16 (11–19) | 15 (10–19) | – |
| Pulmonary hypertension, n | 0 (0) | 0 (0) | – |
| Large ASD‡ | 11 (41) | – | – |
Values are number (percentage) or median (interquartile range). 16 patients had no TR. ASD, Atrial septal defect; BMI, body mass index; LV, left ventricle; RV, right ventricle; FAC, fractional area change; TR, tricuspid valve regurgitant gradient. ‡Patients with right ventricular dilatation or pulmonary artery dilation. *p-value < 0.05 vs. controls, †p-value < 0.05 vs. open ASD.