Table 2.

Primary and secondary outcomes and their associated measurements.

Outcomes					Measurements
Primary outcomes
	Safety			Number of study-related serious adverse events
	Recruitment rate			Number of patients recruited as a proportion of all referred eligible patients
	Retention			Number of intervention participants undergoing end-of-program assessment
	Exposure uptake			Frequency of dietetic and exercise specialist contact (within public hospital system) as a proportion of total scheduled contacts
	Telehealth adherence			Attendance to online exercise and dietetic sessions as a proportion of total scheduled contacts
Secondary outcomes
	Clinical effectiveness
		Metabolic Syndrome Severity Score [31]	Algorithm score comprising systolic blood pressure, diastolic blood pressure, waist circumference, triglycerides, high-density lipoprotein cholesterol, and fasting blood glucose
		Dietary quality	Diet quality assessed by food group intake (frequency per day or week), fiber intake (grams per day), unsaturated oils (grams per day), and discretionary food intake (grams per day)
		Physical activity and sedentary behavior	Time (intensity-weighted minutes) spent in past week as assessed by International Physical Activity Questionnaire (Short Form) and Fitbit weekly physical activity heart rate data
		Exercise capacity	6-Minute Walk Test score
		Neuromuscular fitness	Single chair stand, Five Times Sit to Stand test, hand grip strength
		Muscular pain	Modified Nordic Musculoskeletal Questionnaire
		Quality of life	European Quality of Life Five Dimension Five Level Scale
		Nutrition and physical activity management self-efficacy	Likert confidence scales
		Fatigue	Functional Assessment of Chronic Illness Fatigue Scale score
		Sleep quality and quantity	Pittsburgh Sleep Quality Index score, total Fitbit weekly sleep data
		Additional clinical parameters	Resting heart rate, BMI, serum biochemical analytes (Multimedia Appendix 1)
	Goal attainment			Goal Attainment Scale score
	Treatment fidelity			Treatment notesa Staff attendance at professional support and case discussions
	Exposure demand			Selection of health technology options
	Participant perceptions			Feedback survey Qualitative individual interview data (subsample)

^aParticipant session notes taken by health professionals from telehealth-facilitated sessions with the intervention group.