TABLE 1.

Receptor profile and binding affinities of cariprazine.

Receptor	Binding profile	Affinity category	Ki (nM)
Dopamine type 3	Partial agonist	High	0.085
Dopamine type 2L	Partial agonist	High	0.49
Dopamine type 2S	Partial agonist	High	0.69
Serotonin type 2B	Antagonist	High	0.58
Serotonin type 1A	Partial agonist	High	3.0
Serotonin type 2A	Antagonist	Moderate	19.0
Histamine type 1	Antagonist	Moderate	23.0
Serotonin type 7	Antagonist	Low	111.0
Serotonin type 2C	Antagonist	Low	134.0
Alpha type 1A	Antagonist	Low	155
Muscarinic	Antagonist	No appreciable affinity	IC50 > 1,000

Ki, Inhibition Constant; PDSP, Psychoactive Drug Screening Program. All Ki values have been taken from the PDSD Ki database except for alpha type 1A and muscarinic Ki values that are from Citrome 2015 (4).