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. Author manuscript; available in PMC: 2022 Aug 15.
Published in final edited form as: Nat Genet. 2020 Oct 19;52(12):1283–1293. doi: 10.1038/s41588-020-00731-9

Fig. 4. dACE2 is induced in virally-infected human respiratory cells.

Fig. 4.

Expression patterns of ACE2, represented by Ex1a and Ex1b and dACE2, represented by Ex1c in a-c) uninfected and rhinovirus (RV)-infected human nasal epithelial cells and d-e) in uninfected and influenza H3N2-infected cells from human lung explants. a, RNA-seq Sashimi plots. b, and d, First exon-specific expression levels of ACE2 and dACE2 are presented by box-and-whisker plots as: mean (+), median (center line); box (25th to 75th interquartile range), whiskers (5–90 percentile range) and outliers (individual data points). FC – fold change compared to mock. P-values are for the non-parametric, two-sided Wilcoxon matched-pairs signed rank test. c, and e, Pearson correlation coefficients with p-values for two-sided tests for exon-specific expression levels of ACE2 and dACE2 with select ISGs and IFNs in the full datasets.