Figure 1. P4HA3 was significantly upregulated in obese and type 2 diabetes mellitus (T2DM) patients. A, Venn diagram of the differentially expressed (DE) genes in 2 pairwise comparisons: lean obese, obese (non-diabetic) vs diabetic. B, Top ranked DE genes in both groups (|logFC| ≥1 and P<0.05), with their log2 fold-changes. C, P4HA3 expression in adipose tissue from 30 individuals with normal body mass index (BMI), 30 obese patients, and 30 obese patients with T2DM. Pearson correlation between P4HA3 expression level in adipose tissue and BMI in 30 obese patients (D) and between P4HA3 expression level in adipose tissue and Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) of 30 obese with T2DM patients (E). **P<0.01 (ANOVA).
