Fig. 3.

Dysregulation of cholesterol metabolism in diabetes in bone marrow-derived cells. In control cells, LXR activation leads to increased expression of cholesterol efflux transporters ABCA1 and ABCG1, and inhibition of expression of NF-κB-controlled inflammatory factors. Inhibition of LXR in diabetes leads to cholesterol accumulation, CC formation and increased inflammation. Increased membrane rigidity of reparative cells due to cholesterol accumulation further exacerbates diabetes-induced damage. NCoR, nuclear receptor corepressor; RE, response element. This figure is available as part of a downloadable slideset