Table 3. Risk factors for unsuccessful TB treatment outcome in Northern Red Sea region, 2014–2019 cohort (n = 1227).

	Treatment outcome
Variable	Successful TB treatment outcome	Unsuccessful TB treatment outcome	COR[CI,95%]	AOR[CI,95%]
Sex
Male	614(91.5%)	57(8.5%)	1
Female	494(89.2%)	60(10.8%)	1.31 [0.89–1.92]
Age category
≤ 14	152(94.4%)	9(5.6%)	1	1
15–24	192(95%)	10(5%)	0.88 [0.35–2.22]	0.72[0.28–1.87]
25–34	181(91.4%)	17(8.6%)	1.59 [0.69–3.66]	1.33[0.56–3.13]
35–44	196(90.3%)	21(9.7%)	1.81 [0.81–4.06]	1.56[0.68–3.56]
45–54	190(91.4)	18(8.6%)	1.60 [0.70–3.66]	1.44[0.62–3.34]
55–64	121(85.2%)	21(14.8%)	2.93[1.30–6.63]**	2.76[1.21–6.32]*
≥ 65	77(78.6%)	21(21.4%)	4.61[2.01–10.54]***	4.03[1.72–9.45]**
Residence
Urban	639(90.6%)	66(9.4%)	1
Rural	468(90.4%)	50(9.6%)	0.97[0.66–1.42]
History of TB treatment
New	1050(90.8%)	107(9.2%)	1
Previously treatment	59(84.3%)	11(15.7%)	1.83[0.93–3.59]
Type of TB
Pulmonary TB (bacteriological confirmed)	455(90.6%)	47(9.4%)	1.25[0.78–2.02]
Pulmonary TB (clinical diagnosed)	291(87.6)	41(12.4%)	1.71[1.04–2.80]*
Extra pulmonary TB	363(92.4%)	30(7.6%)	1	1
TB treatment category
Category-I	915(87.9%)	99(12.1%)	1.83[0.87–3.84]	1.17[0.17–7.90]
Category-II	59(84.3%)	11(15.7%)	3.15[1.20–8.22]*	2.16[0.28–16.73]
Category-III	135(94.4%)	8(5.6%)	1	1
HIV status
Negative	1097(90.8%)	111(9.2%)	1	1
Positive	11(61.1%)	7(38.9%)	6.29[2.39–16.55]***	5.13[1.85–13.89]**
Sputum result at 2nd month
Positive	26(74.3%)	9(25.7%)	1
Negative	708(95.5%)	33(4.5%)	0.14[0.06–0.31]***
NA	374(83.5%)	74(16.5%)	0.57 [0.26–1.27]
Health facility
Afabet Hospital	397(96.8%)	13(3.2%)	1
Ghindae Regional Referral Hospital	245(84.8%)	44(15.2%)	5.48[2.90–10.39]***	5.01[2.61–9.61]***
Massawa Hospital	298(86.4%)	47(13.6%)	4.82[2.56–9.06]***	4.35[2.28–8.30]***
Nakfa Hospital	169(92.4%)	14(7.6%)	2.53[1.16–5.50]*	2.53[1.15–5.53]*

N.B. P< 0.05(*), P< 0.01(**), P< 0.001(***)