Table 1. Protein relative expression levels (x ± standard deviation, p)*.
Control group | DN group | Low-dose GEN group | High-dose GEN group | |
---|---|---|---|---|
NOX4 | 1.00 ± 0.05 | 2.21 ± 0.04***, 0.000 | 2.00 ± 0.08##, 0.001 | 1.67 ± 0.02### @@@, 0.000 |
mfn2 | 1.00 ± 0.04 | 1.48 ± 0.03***, 0.000 | 1.82 ± 0.04###, 0.000 | 2.33 ± 0.08### @@@, 0.000 |
p38 | 1.00 ± 0.08 | 2.63 ± 0.04***, 0.000 | 2.29 ± 0.07###, 0.000 | 2.00 ± 0.08### @@@, 0.000 |
p65 | 1.00 ± 0.07 | 2.39 ± 0.01***, 0.000 | 1.86 ± 0.03###, 0.000 | 1.57 ± 0.03### @@@, 0.000 |
p53 | 0.99 ± 0.06 | 3.08 ± 0.04***, 0.000 | 2.52 ± 0.04###, 0.000 | 2.21 ± 0.80### @@@, 0.000 |
DN: diabetic nephropathy; GEN: genistein;
values are expressed as mean ± standard deviation, n = 5 per group;
p < 0.001 vs. control group;
p < 0.01 DN group;
p < 0.001 DN group;
p < 0.001 vs. low-dose GEN group.