Table 1.
Patient demographics and baseline characteristics.
| Patient demographics/characteristics | PSOC | PROC | Total |
|---|---|---|---|
| (n = 90) | (n = 23) | (N = 113) | |
| Median age, years (range) | 54 (39–79) | 54 (34–66) | 54 (34–79) |
| <65 years, n (%) | 80 (88.9) | 21 (91.3) | 101 (89.4) |
| ECOG score, n (%) | |||
| 0 | 42 (46.7) | 10 (43.5) | 52 (46.0) |
| 1 | 48 (53.3) | 13 (56.5) | 61 (54.0) |
| Number of prior lines of systemic chemotherapy (grouped), n (%) | |||
| 2 | 52 (57.8) | 3 (13.0) | 55 (48.7) |
| 3 | 19 (21.1) | 10 (43.5) | 29 (25.7) |
| 4 | 8 (8.9) | 6 (26.1) | 14 (12.4) |
| 5 | 4 (4.4) | 1 (4.3) | 5 (4.4) |
| ≥6 | 7 (7.8) | 3 (13.0) | 10 (8.8) |
| gBRCA status, n (%) | |||
| BRCA1 mutation | 79 (87.8) | 19 (82.6) | 98 (86.7) |
| BRCA2 mutation | 11 (12.2) | 4 (17.4) | 15 (13.3) |
| Years from initial diagnosis, median (range) | 3.9 (1.4–13.6) | 3.6 (1.1–7.1) | 3.9 (1.1–13.6) |
| Primary tumor location at initial diagnosis, n (%) | |||
| Ovary | 81 (90.0) | 20 (87.0) | 101 (89.4) |
| Fallopian tube | 7 (7.8) | 3 (13.0) | 10 (8.8) |
| Peritoneum | 1 (1.1) | 0 | 1 (0.9) |
| Undesignated | 1 (1.1) | 0 | 1 (0.9) |
| Histology, n (%) | |||
| Serous epithelial tumors | 85 (94.4) | 23 (100.0) | 108 (95.6) |
| Endometrioid epithelial tumors | 4 (4.4) | 0 | 4 (3.5) |
| Mixed epithelial tumors | 1 (1.1) | 0 | 1 (0.9) |
| Target lesion diameter per IRC at study entry (mm), n (%) | |||
| <50 | 41 (45.6) | 8 (34.8) | 49 (43.4) |
| ≥50 | 41 (45.6) | 11 (47.8) | 52 (46.0) |
| Missing | 8 (8.9) | 4 (17.4) | 12 (10.6) |
| CA-125 value at study entry (kU/L), n (%) | |||
| <70 | 16 (17.8) | 2 (8.7) | 18 (15.9) |
| ≥70 | 74 (82.2) | 21 (91.3) | 95 (84.1) |
Abbreviations: BRCA, breast cancer susceptibility gene; ECOG, Eastern Cooperative Oncology Group.