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. 2021 Dec 13;28(4):781–792. doi: 10.1158/1078-0432.CCR-21-3140

Figure 4.

Figure 4. Clinical impact of immune checkpoint–expressing macrophages in the DLBCL microenvironment. A, A forest plot visualizing the impact of immune checkpoint–expressing macrophages on OS in the mIHC cohort, as evaluated by Cox regression univariate analyses with continuous variables. B, Kaplan–Meier (log-rank test) survival plots depict OS in patients with high and low proportion of PD-L1+TIM3+CD163− macrophages using median cutoff in the mIHC cohort. C–E, Forest plots visualizing the impact of PD-L1+TIM3+CD163− macrophages on OS in Cox regression multivariate analyses with IPI (C), IPI and molecular subtype (D), and IPI, molecular subtype and double protein expression (E) in the mIHC cohort. F and G, Forest plots visualizing the impact of immune checkpoint–expressing macrophages on OS in the T cell–high (F) and low (G) groups, as evaluated by Cox regression univariate analyses with continuous variables in the mIHC cohort. H, Forest plot visualizing the impact of the gene expression of immune checkpoint molecules in macrophages/monocytes, inferred with CIBERSORTx, on OS in the T cell–high group in the Reddy and colleagues' cohort, as evaluated by Cox regression univariate analyses with continuous variables. *, P ≤ 0.05 after FDR correction.

Clinical impact of immune checkpoint–expressing macrophages in the DLBCL microenvironment. A, A forest plot visualizing the impact of immune checkpoint–expressing macrophages on OS in the mIHC cohort, as evaluated by Cox regression univariate analyses with continuous variables. B, Kaplan–Meier (log-rank test) survival plots depict OS in patients with high and low proportion of PD-L1+TIM3+CD163− macrophages using median cutoff in the mIHC cohort. C–E, Forest plots visualizing the impact of PD-L1+TIM3+CD163− macrophages on OS in Cox regression multivariate analyses with IPI (C), IPI and molecular subtype (D), and IPI, molecular subtype and double protein expression (E) in the mIHC cohort. F and G, Forest plots visualizing the impact of immune checkpoint–expressing macrophages on OS in the T cell–high (F) and low (G) groups, as evaluated by Cox regression univariate analyses with continuous variables in the mIHC cohort. H, Forest plot visualizing the impact of the gene expression of immune checkpoint molecules in macrophages/monocytes, inferred with CIBERSORTx, on OS in the T cell–high group in the Reddy and colleagues' cohort, as evaluated by Cox regression univariate analyses with continuous variables. *, P ≤ 0.05 after FDR correction.