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. 2021 Dec 13;28(5):993–1003. doi: 10.1158/1078-0432.CCR-21-2498

Figure 1.

Figure 1. RPPA analysis of cell signaling proteins from frozen tumor samples in FAIRLANE study. A, Schematic showing the collection of baseline and cycle 1 day 8 (C1D8) tumor samples for RPPA analysis. Venn diagram shows the number of the baseline and C1D8 RPPA samples. B, Correlation plot showing the pair-wise correlation between all endpoints measured by RPPA at baseline. The AKT and mTORC1 downstream components cluster tightly together shown in the zoomed plot. C, Diagram of the AKT/mTORC1 signaling pathway highlighting the phosphorylation sites measured by RPPA in this study. pAKT activity, AKT score, and mTORC1 score were calculated by the phosphorylation levels of AKT itself, AKT, and mTORC1 direct substrates, respectively.

RPPA analysis of cell signaling proteins from frozen tumor samples in FAIRLANE study. A, Schematic showing the collection of baseline and cycle 1 day 8 (C1D8) tumor samples for RPPA analysis. Venn diagram shows the number of the baseline and C1D8 RPPA samples. B, Correlation plot showing the pair-wise correlation between all endpoints measured by RPPA at baseline. The AKT and mTORC1 downstream components cluster tightly together shown in the zoomed plot. C, Diagram of the AKT/mTORC1 signaling pathway highlighting the phosphorylation sites measured by RPPA in this study. pAKT activity, AKT score, and mTORC1 score were calculated by the phosphorylation levels of AKT itself, AKT, and mTORC1 direct substrates, respectively.