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. 2022 May 2;21(7):1207–1218. doi: 10.1158/1535-7163.MCT-21-0840

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©2022 The Authors; Published by the American Association for Cancer Research

This open access article is distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) license.

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Figure 4. Bexmarilimab does not induce cytokine release in whole blood. Release of cytokines (A) IL6 (A), IL10 (B), IFNγ (C), TNFα (D), and IL8 (E) upon bexmarilimab treatment of human whole blood as determined by Cytokine ScreenTM assay. Alemtuzumab and cetuximab were used as reference compounds. Each data point represents one donor(N = 21) and the graphs show the median, minimum, and maximum values. F, Cytokines induced by positive control [pokeweed mitogen (PWM)] compared with PBS. Statistical analysis was performed using one-way ANOVA followed by paired Student t test. ***, P < 0.001; ****, P < 0.0001 as compared with cetuximab. — Bexmarilimab does not induce cytokine release in whole blood. Release of cytokines (A) IL6 (A), IL10 (B), IFNγ (C), TNFα (D), and IL8 (E) upon bexmarilimab treatment of human whole blood as determined by Cytokine Screen^TM assay. Alemtuzumab and cetuximab were used as reference compounds. Each data point represents one donor (n = 21) and the graphs show the median, minimum, and maximum values. F, Cytokines induced by positive control [pokeweed mitogen (PWM)] compared with PBS. Statistical analysis was performed using one-way ANOVA followed by paired Student t test. ***, P < 0.001; ****, P < 0.0001 as compared with cetuximab.