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Affinity of bexmarilimab for human and cynomolgus monkey Clever-1 as determined by SPR analysis.
| A. Antibody | K D x 10–9 (M) | K a x 105 (1/Ms) | K d x 10–4 (1/Ms) |
|---|---|---|---|
| 3–372 | 0.55 | 2.3 | 1.2 |
| VH3/VK5 | 0.65 | 3.7 | 2.4 |
| Bexmarilimab | 0.75 | 3.1 | 2.4 |
| B. Antigen | K D x 10–9 (M) | K a x 105 (1/Ms) | K d x 10–4 (1/Ms) |
| Human Clever-1 | 0.75 | 3.1 | 2.8 |
| Cynomolgus Clever-1 | 0.92 | 3.6 | 3.3 |
Abbreviations: KD, affinity constant; Ka, association constant; Kd, dissociation constant.
