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. 2022 May 2;21(7):1136–1148. doi: 10.1158/1535-7163.MCT-21-0791

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©2022 The Authors; Published by the American Association for Cancer Research

This open access article is distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) license.

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Figure 1. In vitro treatment of B16-huCD20 cells with 177Lu-9079 induces cell death that coincides with exposure of calreticulin and release of ATP. B16-huCD20 cells were treated for 1 hour with 370 MBq/mL 177Lu-R3B23 [CTRL (370 MBq/mL)] or 177Lu-9079 [TRT (dose)] or 48 hours of 2 μmol/L MTX (2 μmol/L), respectively. Flow cytometry was performed 48 hours after addition of 177Lu-sdAb to study the percentage of dead cells (A), cell surface calreticulin on viable cells (B), and ATP-release by viable cells (C). The bar graphs show individual datapoints and grouped mean ± SD (N = 1, n = 3). — In vitro treatment of B16-huCD20 cells with ¹⁷⁷Lu-9079 induces cell death that coincides with exposure of calreticulin and release of ATP. B16-huCD20 cells were treated for 1 hour with 370 MBq/mL ¹⁷⁷Lu-R3B23 [CTRL (370 MBq/mL)] or ¹⁷⁷Lu-9079 [TRT (dose)] or 48 hours of 2 μmol/L MTX (2 μmol/L), respectively. Flow cytometry was performed 48 hours after addition of ¹⁷⁷Lu-sdAb to study the percentage of dead cells (A), cell surface calreticulin on viable cells (B), and ATP-release by viable cells (C). The bar graphs show individual datapoints and grouped mean ± SD (N = 1, n = 3).