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. 2022 May 2;21(7):1136–1148. doi: 10.1158/1535-7163.MCT-21-0791

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©2022 The Authors; Published by the American Association for Cancer Research

This open access article is distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) license.

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Figure 4: Peripheral immune responses upon treatment with 177Lu-9079. Multiplex analysis of serum cytokine levels of IL10 (A) and CCL5 (B) was performed on serum isolated 6 hours after last administration of 50 MBq or 140 MBq of 177Lu-9079 [TRT (50 MBq) and TRT (140 MBq), respectively], or 140 MBq 177Lu-R3B23 [CTRL (140 MBq)]. The graphs represent the results as individual values with grouped mean ± SD (N = 1, n = 4). C, Agarose gel visualizing amplicons resulting from the PCR reaction with gp100 (90 bp), Trp2 (71 bp), ADPGK (400 bp), and ovalbumin (346 bp) specific primer sets. D, Analysis of IFNγ production by CD8pos splenocytes stimulated with antigen-derived peptides. E, Analysis of IFN-γ production by CD8pos splenocytes stimulated with anti-CD3/CD28 antibody-coated beads. D and E, The graphs represent the results as individual values with grouped mean ± SD (N = 1, n = 6). — Peripheral immune responses upon treatment with ¹⁷⁷Lu-9079. Multiplex analysis of serum cytokine levels of IL10 (A) and CCL5 (B) was performed on serum isolated 6 hours after last administration of 50 MBq or 140 MBq of ¹⁷⁷Lu-9079 [TRT (50 MBq) and TRT (140 MBq), respectively], or 140 MBq ¹⁷⁷Lu-R3B23 [CTRL (140 MBq)]. The graphs represent the results as individual values with grouped mean ± SD (N = 1, n = 4). C, Agarose gel visualizing amplicons resulting from the PCR reaction with gp100 (90 bp), Trp2 (71 bp), ADPGK (400 bp), and ovalbumin (346 bp) specific primer sets. D, Analysis of IFNγ production by CD8^pos splenocytes stimulated with antigen-derived peptides. E, Analysis of IFN-γ production by CD8^pos splenocytes stimulated with anti-CD3/CD28 antibody-coated beads. D and E, The graphs represent the results as individual values with grouped mean ± SD (N = 1, n = 6).