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. 2022 May 2;21(7):1136–1148. doi: 10.1158/1535-7163.MCT-21-0791

Figure 5.

Figure 5. NanoString RNA profiling of tumors treated with 50 or 140 MBq of 177Lu-9079 [TRT (50 MBq) and TRT (140 MBq), respectively], or 140 MBq 177Lu-R3B23 [CTRL (140 MBq)] shows a different gene expression profile. RNA was isolated from tumors with an average volume of 250 mm³. RNA samples with RNA Integrity values of 7.81 ± 0.35 were subjected to RNA profiling. A, Representation of the GSEA on gene expression changes in B16-huCD20 tumors treated with 50 MBq (right) or 140 MBq (left) 177Lu-9079 compared with 140 MBq 177Lu-R3B23. The color of the sphere indicates whether an increase (red) or decrease (blue) in the respective pathway has been observed. Immune and cell metabolism pathways are displayed. Pathways annotated with “*” and “**”, originate from the canonical pathways and hallmarks databases, while unmarked pathways originate from the Gene Ontology database. B, Immune cell scoring. The data are represented as 10 to 90 percentile Box and Whiskers (N = 1, n = 3). Tregs, regulatory T cells.

NanoString RNA profiling of tumors treated with 50 or 140 MBq of 177Lu-9079 [TRT (50 MBq) and TRT (140 MBq), respectively], or 140 MBq 177Lu-R3B23 [CTRL (140 MBq)] shows a different gene expression profile. RNA was isolated from tumors with an average volume of 250 mm³. RNA samples with RNA Integrity values of 7.81 ± 0.35 were subjected to RNA profiling. A, Representation of the GSEA on gene expression changes in B16-huCD20 tumors treated with 50 MBq (right) or 140 MBq (left) 177Lu-9079 compared with 140 MBq 177Lu-R3B23. The color of the sphere indicates whether an increase (red) or decrease (blue) in the respective pathway has been observed. Immune and cell metabolism pathways are displayed. Pathways annotated with “*” and “**”, originate from the canonical pathways and hallmarks databases, while unmarked pathways originate from the Gene Ontology database. B, Immune cell scoring. The data are represented as 10 to 90 percentile Box and Whiskers (N = 1, n = 3). Tregs, regulatory T cells.