Table 1. Factors predicting the development of leptomeningeal metastasis.
| Variable | Variable factors | Leptomeningeal metastasis (%) | OR (95%CI) | p-value |
|---|---|---|---|---|
| Age | Elderly (n = 439) | 12 (2.7) | 0.89 (0.44–1.8) | 0.745 |
| Non-elderly (n = 709) | 24 (3.4) | Reference | ||
| Gender | Male (n = 744) | 23 (3.1) | 0.567 (0.283–1.135) | 0.109 |
| Female (n = 404) | 13 (3.2) | Reference | ||
| ECOG PS | ECOG PS 0-1 (n = 1,033) | 30 (2.9) | 0.674 (0.269–1.687) | 0.399 |
| ECOG PS 2 (n = 115) | 8 (5.2) | Reference | ||
| Histopathology | Non-squamous (n = 858) | 35 (4.1%) | 2.731 (0.32–23.318) | 0.359 |
| Squamous (n = 290) | 1 (0.3%) | Reference | ||
| Driver mutation status | Present (n = 658) | 31 (4.7) | Reference | 0.064 |
| Absent (n = 490) | 5 (1) | 0.379 (0.136–1.058) | ||
| Brain metastasis | Present (n = 153) | 10 (6.5) | Reference | 0.035 |
| Absent (n = 995) | 26 (2.6) | 0.45 (0.214–0.946) |
ECOG PS, Eastern Oncology Cooperative Group performance status; OR, odds ratio; CI, confidence interval.