Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Sep 30;130(8):498–508. doi: 10.1055/a-1608-0607

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License, which permits unrestricted reproduction and distribution, for non-commercial purposes only; and use and reproduction, but not distribution, of adapted material for non-commercial purposes only, provided the original work is properly cited.

PMC Copyright notice

Fig. 1 — Acute FAM3A knockdown significantly impaired insulin secretion. Male C57BL/6 mice were injected with scramble or siFAM3A via tail vein hydrodynamic injection. ( a ) An oral glucose tolerance test (OGTT) was performed before siRNA injection. The area under the curve (AUC) of OGTT (day 0) is presented in the right panel. ( b ) OGTT on day 3 after tail injection of scramble or siFAM3A is shown. AUC of OGTT (day 3) is presented in the right panel. ( c ) Three days after siRNA injection, blood samples were collected from the tail vein at the first four time points (0, 15, 30, and 60 min) of OGTT, and serum insulin levels were measured. The AUC of serum insulin is presented in the right panel. ( d ) Insulin content in islets of mice with acute FAM3A inhibition and the scramble group. ( e ) Glucose-stimulated insulin secretion in the scramble and siFAM3A groups. For (a-c), N=14–18. For (d-e), N=6. For (a-d), *P<0.05 vs. scramble group. For ( e ), *P<0.05 vs. scramble islets (G0), #P<0.05 between siFAM3A islets vs. corresponding scramble group under G0, G5, and G20 stimulation separately. G0: 0 mmol/L, G5: 5 mmol/L, and G20: 20 mmol/L glucose.