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. 2022 Aug 8;2022:4776243. doi: 10.1155/2022/4776243

Figure 2.

Figure 2

Melatonin treatment alleviates IR-induced acute kidney injury in mice. (a) Serum ALT. (b–d) BUN, serum creatinine (Scr), and Ccr level; the result shows that MT or Fer-1 could alleviate the kidney injury in IR-AKI. (f, g) Representative image of HE and PAS revealed that renal tubular injury induced by IR was partly reversed by MT and Fer-1 treatment, and renal tubular damage was scored semiquantitatively (right panel). (e) Real-time PCR and (f) immunohistochemistry were used to measure the expression of KIM-1 in kidney tissues. (i) TUNEL staining and scores. Data represent the mean ± SEM of six mice in each group. ∗p < 0.05,  ∗∗p < 0.01, and∗∗∗p < 0.001 compared to the Sham and Sham+MT (20 mg/kg) groups. #p < 0.05,  ##p < 0.01, and###p < 0.001 compared to the IR-treated group. Scale bar = 50-100 μm.