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. 2022 Aug 8;2022:8619275. doi: 10.1155/2022/8619275

Figure 1.

Figure 1

DLL inhibited 3LL tumor growth both in vitro and in vivo. (a) 3LL tumor cells were treated for 24, 48, and 72 h in a 96-well plate in the presence of different doses of DLL (0, 5, 25, 50, and 100 μg/ml). CCK-8 assay was used to estimate the cell viability. Cell viability was decreased with increased DLL concentration. (b, c) Nude mice (b) and C57BL/6 mice (c) were injected subcutaneously with 5 × 104 3LL tumor cells per mouse. DLL was injected subcutaneously on day 4 and then once every day for a total of seven injections. Saline was injected subcutaneously as a control. DLL injection significantly inhibited tumor growth in C57BL/6 mice. Data are the mean ± SD from three independent experiments. ∗∗P < 0.01 and∗∗∗P < 0.001 by Student's t-test, N = 6. DLL: delicaflavone.