Table 1.
ID | Age/gender | Infection timea | Pango lineage | Seq. interval | Comorbidities | Symptoms | Immunosuppressive medicationb | Complications | ICU | Ventilationc | Treatment (R/D/P)d | Outcome |
---|---|---|---|---|---|---|---|---|---|---|---|---|
P01 | 53 F | 90 | B.1.8 | 0–83 days | Follicular lymphoma (in remission) | Dyspnea, cough | Obinutuzumab (3 months prior to admission) | Pneumonia | No | – | R (d63-d72/d91-95), P (d95; d97, d99) |
Discharged with no symptoms on day 138 |
P03 | 34 M | 30 | A | 0–28 days | Diabetes, renal failure, adiposity | Cough, fever | – | – | No | LFOT | R (d9/d12) | Discharged with no symptoms on day 33 |
P05 | 61 M | 65 | B.1.36.1 | 0–65 days | Diabetes | Hypoxia with accompanying syncope | – | Severe ARDS, septic shock, acute renal failure | Yes | Invasive | D (continuously), Hydrocortisone (d4-12) | Discharged with no symptoms on day 87 |
P06 | 43 M | 47 | B.1.177.81 | 0–46 days | Pre-diabetes, adiposity | Dyspnea, cough | – | Severe ARDS, acute renal failure, septic shock | Yes | Invasive | D (d2-d18), Hydrocortisone | Transfer to rehabilitation center on day 35 |
P07 | 75 F | 57 | B.1.1 | 0–47 days | Renal failure, granulomatosis with polyangiitis, hypertension | Dyspnea, cough | Cyclophosphamide (1 month prior to admission) | Severe ARDS | Yes | LFOT/HFOT/invasive | D (d35-d41) | Discharged with atrial fibrillation and dyspnea on day 43 |
P08 | 50 F | 38 | B.1.1 | 0–24 days | Diabetes, adiposity, hypertension | Pyrexia, dyspnea, nausea, cephalalgia | – | Severe ARDS, acute renal failure, asystole with successful cardiopulmonary resuscitation | Yes | Invasive | D (before admission and d12-d16) | Discharged with Dyspnea and on day 41 |
P09 | 62 M | 39 | B.1.177.81 | 0–12 days | Diabetes, adiposity, hypertension | Pyrexia, dyspnea, fatigue | – | Severe ARDS, acute renal failure, pneumogenic sepsis | Yes | LFOT/HFOT/invasive | D (before admission and d1-d9) | Discharged with no symptoms on day 54 |
P10 | 75 M | 55 | A | 0–24 days | COPD, adiposity, hypertension | Progressive pulmonary failure | – | Moderate ARDS, acute renal failure, sepsis, circulatory failure with successful cardiopulmonary resuscitation | Yes | Invasive | – | Discharged with no symptoms on day 56 |
P13 | 60 F | 57 | A | 0–57 days | Rheumatoid arthritis | – | Methotrexate (weekly) Rituximab (most recent administration unknown) |
Severe ARDS, acute renal failure, sepsis | Yes | LFOT/invasive | R (before admission and d9-15), D (before admission and d9 –d39) | Deceased 41 days after admission, septic shock with multi-organ failure |
P14 | 59 M | 57 | B.1.1.277 | 0–29 days | Liver transplant recipient, hypertension | Dyspnea | Tacrolimus (on admission) Basiliximab (most recent administration unknown) |
Pneumonia | Yes | LFOT/HFOT/invasive | D (d20 – d24) | Discharged with no symptoms on day 67 |
P15 | 70 F | 63 | AC.1 | 0–33 days | Diabetes, adiposity, hypertension | Dyspnea, cough | – | Severe ARDS, heparin induced thrombocytopenia | Yes | Invasive | D (d4 - d6) | Discharged with no symptoms on day 66 |
P16 | 75 M | 26 | B.1 | 0–25 days | COPD, hypertension | Pyrexia, dyspnea, fatigue, progressive pulmonary failure | – | ARDS, acute atrial fibrillation, acute renal failure, intrahepatic cholestasis | Yes | Invasive | Prednisolone | Discharged with no symptoms on day 92 |
P17 | 77 M | 52 | B.1.1 | 0–13 days | COPD, rheumatoid arthritis, hypertension, diabetes, renal failure | Dyspnea, pyrexia, diarrhea | Methotrexate (weekly) | Severe ARDS, acute renal failure, multiple septic episodes, critical illness polyneuropathy, and myopathy | Yes | LFOT/invasive | Prednisolone, Hydrocortisone continuously |
Discharged with no respiratory symptoms on day 205 |
P18 | 66 F | 146 | A.9 | 0–117 days | Dementia, hypertension, adiposity, renal failure, Goodpasture syndrome | Dyspnea, altered vigilance | Single dose rituximab, cyclophosphamide (8–10 months prior to admission) | ARDS, AV block I°, sepsis, cardiac decompensation (NYHA IV) | Yes | HFOT/invasive | Hydrocortisone for 3days, Prednisolone continuously |
Discharged with no symptoms on day 160 |
Interval between admission to the hospital and last qRT-PCR positive SARS-CoV-2 report in the respiratory tract.
Immunosuppressive medication upon admission.
LFOT: low-flow oxygen therapy; HFOT: high-flow oxygen therapy.
D: dexamethasone; R: remdesivir; P: convalescent plasma.