Table 2:

Univariable and multivariable Cox proportional hazards regression model of the entire cohort.

Factor	Hazard Ratio (95% CI)	p Value	Hazard Ratio (95% CI)	p Value
	Univariate		Multivariate
Lymphovascular Invasion	1.270 (1.216–1.328)	<0.001	1.156 (1.102–1.211)	<0.001
Perineural Invasion	1.348 (1.271–1.429)	<0.001	1.281 (1.205–1.362)	<0.001
Inadequate Lymph Node Harvest	1.735 (1.647–1.828)	<0.001	1.643 (1.557–1.733)	<0.001
High Grade (3–4)	1.229 (1.178–1.283)	<0.001	1.105 (1.057–1.155)	<0.001
T3	--		--	--
T4A	1.629 (1.544–1.718)	<0.001	1.670 (1.577–1.769)	<0.001
T4B	1.696 (1.596–1.802)	<0.001	2.049 (1.919–2.189)	<0.001
Positive Resection Margin	2.023 (1.884–2.171)	<0.001	1.659 (1.535–1.792)	<0.001
Age >65	3.149 (3.016–3.287)	<0.001	2.741 (2.619–2.868)	<0.001
CDCS 0	--		--
CDCS 1	1.406 (1.352–1.462)	<0.001	1.255 (1.205–1.306)	<0.001
CDCS 2	2.211 (2.094–2.335)	<0.001	1.840 (1.741–1.945)	<0.001
CDCS 3	2.770 (2.582–2.973)	<0.001	2.244 (2.088–2.410)	<0.001
Received Adjuvant Chemotherapy	0.535 (0.507–0.564)	<0.001	0.570 (0.537–0.605)	<0.001