Table 3:

Univariable and multivariable Cox proportional hazards regression model of patients under 65 years old with no comorbidities, n=16,689.

Factor	Hazard Ratio (95% CI)	p Value	Hazard Ratio (95% CI)	p Value
	Univariate		Multivariate
Lymphovascular Invasion	1.346 (1.188–1.525)	<0.001	1.170 (1.021–1.340)	0.023
Perineural Invasion	1.644 (1.418–1.907)	<0.001	1.429 (1.219–1.676)	<0.001
Inadequate Lymph Node Harvest	1.927 (1.652–2.248)	<0.001	1.929 (1.642–2.266)	<0.001
High Grade (3–4)	1.137 (0.996–1.299)	0.058	1.080 (0.939–1.243)	0.282
T3	--		--
T4A	2.162 (1.879–2.487)	<0.001	2.171 (1.862–2.531	<0.001
T4B	2.767 (2.422–3.162)	<0.001	2.768 (2.376–3.225)	<0.001
Positive Resection Margin	3.080 (2.614–3.628)	<0.001	2.150 (1.792–2.580)	<0.001
Received Adjuvant Chemotherapy	1.039 (0.937–1.152)	0.473	0.657 (0.585–0.739)	<0.001