TABLE 3.
Association of orthostatic hypotension with falls, N = 534 participants
Seated |
Supine |
|||
---|---|---|---|---|
HR (95% CI) | p | HR (95% CI) | p | |
OH | 0.69 (0.30, 1.58) | 0.38 | 1.55 (0.95, 2.52) | 0.08 |
Systolic OH | 0.38 (0.10, 1.36) | 0.14 | 1.77 (1.02, 3.05) | 0.04 |
Diastolic OH | 0.91 (0.38, 2.23) | 0.84 | 1.58 (0.88, 2.84) | 0.13 |
Note: Hazard ratios for time-to-fall were determined via Cox proportional hazards models. Falls were treated as recurrent events. Orthostatic hypotension was a time-varying covariate updated at pre-defined study time points (pre-randomization, 3-, 12-, and 24-month visits. Models were adjusted for age, sex, race, and field center. We ultimately did not display associations of difference in systolic and diastolic blood pressure with falls since these were not linear (see splines in Supporting information). Abbreviations: CI, confidence interval; HR, hazard ratio; OH, orthostatic hypotension.