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. Author manuscript; available in PMC: 2023 Aug 18.
Published in final edited form as: Platelets. 2022 May 26;33(6):823–832. doi: 10.1080/09537104.2022.2071852

Figure 1.

Figure 1.

A schematic illustrating the shear-resistant and shear-responsive characteristics of GPIb-IX binding to VWF A1 domain. Left: GPIbα with folded mechanosensory domain (MSD) prior to VWF binding. Right: VWF binds to GPIbα via a shear force-resistant “catch bond”. Shear force, via GPIb-bound VWF, unfolds MSD of GPIbα, which subsequently changes the conformation of the transmembrane complex of GPIb-IX, resulting in cross-membrane signal transduction and regulating the interactions with proteins important for GPIb-IX-initiated intracellular signaling.