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. Author manuscript; available in PMC: 2023 Aug 1.
Published in final edited form as: Mol Neurobiol. 2022 Jun 7;59(8):5104–5120. doi: 10.1007/s12035-022-02905-4

Figure 8. A schematic model illustrating a role of WDR5 in dendrite polarity.

Figure 8.

(A) A schematic model of target gene regulation of WDR5. WDR5 interact with lnc RNA, HOTTIP and histone modification complexes and regulation of target gene transcription. (B) WDR5 regulates apical dendrite polarity and extension. Control neurons elongate single long apical dendrite toward the pial surface and branching their dendrites nearby pial surface. In contrast, WDR5-suppressed neurons develop multiple apical dendrites and branched irregularly their dendrite in cortical layer I