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. Author manuscript; available in PMC: 2023 Aug 11.
Published in final edited form as: J Med Chem. 2022 Jul 27;65(15):10611–10625. doi: 10.1021/acs.jmedchem.2c00807

Figure 1.

Figure 1.

Design of putative NSD2 degraders 1–11. (A) Chemical structure of the NSD2 PWWP1 binder UNC6934. (B) Crystal structure of the NSD PWWP1 domain (gray) in complex with UNC6934 (blue) (PDB 6XCG). The pyrimidine ring of UNC6439 (highlighted by the red dashed circle) is solvent exposed. Key residues of NSD2 are shown in gray. Hydrogen bond interactions between UNC6439 and the key residues of the NSD2 PWWP1 domain are highlighted by yellow dashed lines. (C) Chemical structures of putative NSD2 degraders 1–11.