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. Author manuscript; available in PMC: 2023 Aug 11.
Published in final edited form as: J Med Chem. 2022 Jul 27;65(15):10611–10625. doi: 10.1021/acs.jmedchem.2c00807

Figure 10.

Figure 10.

Compound 9 inhibits the proliferation in multiple myeloma cells. (A,B) The effect of compounds 9, 17, and 18 as well as UNC6934 on inhibiting the proliferation of KMS11 (A) and H929 (B) cells. The cells were treated with DMSO, 9, 17, 18, or UNC6934 at 2.5 μM for 8 days. (C,D) The effect of compound 9 (2.5 μM), relative to DMSO, and shRNA-mediated KD of NSD2 (sh#2), relative to transduction of empty vector (shEV), on inhibiting the proliferation in KMS11(C) and H929 (D) cells. The relative cell viabilities to the corresponding control group are shown as the mean ± SD (n = 3).