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. Author manuscript; available in PMC: 2023 Aug 11.
Published in final edited form as: J Med Chem. 2022 Jul 27;65(15):10611–10625. doi: 10.1021/acs.jmedchem.2c00807

Scheme 2. Synthesis of Negative Controls 17 and 18a.

Scheme 2.

aReaction conditions: (a) NMP, DIPEA, MW, 100 °C, tert-butyl glycinate; (b) DCM, TFA, rt; (c) HOAT, EDCI, NMM, DMSO, rt; (d) SOCl2, 40 °C, then 15, pyridine, DMAP, rt.